percutaneous microwave ablation of thyroid nodules: efficacy evaluation with 99m tc - pertechnetate and 99mtc-mibi functional imaging

نویسندگان

k. heck department of nuclear medicine, frankfurt university hospital, frankfurt, germany

y. korkusuz department of nuclear medicine, frankfurt university hospital, frankfurt, germany

c. happel department of nuclear medicine, frankfurt university hospital, frankfurt, germany

f. grünwald department of nuclear medicine, frankfurt university hospital, frankfurt, germany

چکیده

background: local ablative treatments play an important role for patients who cannot be treated surgically. radiofrequency ablation is a well-established alternative to surgical treatment of thyroid nodules, however it also has disadvantages. microwave ablation (mwa) is a new minimally invasive treatment promising several improvements. the aim of this retrospective study was to evaluate the effects of microwave ablation on thyroid nodules by 99mtc-pertechnetate and 99mtc-mibi scintigraphy. materials and methods: 30 patients with overall 40 nodules were treated. for the ablation of thyroid nodules, a microwave generator working with frequencies from 902 to 928 mhz was used. the ablation time ranged between 120 and  300 seconds per ablation zone. the target temperatures ranged between 60-80 °c. pre- and post- interventional, the radionuclide uptake was determined using a thyroid specific scintillation camera. for 27 cold nodules 99mtc-mibi was used for evaluation; 13 indifferent nodules were measured with 99mtc-pertechnetate. results: the relative change of uptake was detected as a quotient of pre- and post- therapeutic uptake. the statistical analysis of scintigraphy data proved the efficacy of microwave ablation. 99mtc-pertechnetate scintigraphy  showed an uptake reduction of 39% (range 9 to 85%). 99mtc-mibi imaging showed a median reduction of 40% (p<0.01) (range 7 to 100%). conclusion: the determined results show the effectiveness of mwa as a treatment option for benign thyroid nodules. with functional scintigraphy a significant activity decrease could be detected in the ablation zone; hence a verification of affectivity was possible after a short period of time.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Percutaneous microwave ablation of thyroid nodules: efficacy evaluation with 99m Tc - pertechnetate and 99mTc-MIBI functional imaging

Background: Local ablative treatments play an important role for patients who cannot be treated surgically. Radiofrequency ablation is a well-established alternative to surgical treatment of thyroid nodules, however it also has disadvantages. Microwave ablation (MWA) is a new minimally invasive treatment promising several improvements. The aim of this retrospective study was to evaluate the eff...

متن کامل

Percutaneous microwave ablation of thyroid nodules: efficacy evaluation with 99m Tc - pertechnetate and 99mTc-MIBI functional imaging

Background: Local abla ve treatments play an important role for pa ents who cannot be treated surgically. Radiofrequency abla on is a well-established alterna ve to surgical treatment of thyroid nodules, however it also has disadvantages. Microwave abla on (MWA) is a new minimally invasive treatment promising several improvements. The aim of this retrospec ve study was to evaluate the effects o...

متن کامل

Diagnostic accuracy of elastography and scintigraphic imaging after thermal microwave ablation of thyroid nodules.

PURPOSE The aim of this study is to evaluate structural alterations of thyroid tissue after microwave ablation using elastography and scintigraphic imaging to investigate the applicability of these diagnostic methods for follow-up.  MATERIALS AND METHODS 35 patients with 39 thyroid nodules were evaluated using elastography and scintigraphic imaging before and after ultrasound-guided microwave...

متن کامل

99mTc-MIBI imaging in thyroid nodules: is it useful?

Treglia et al. [1] have recently proposed a meta-analysis evaluating the diagnostic performance of 99mTc-MIBI scan in predicting the malignancy of thyroid nodules. 99m-Tc is registered and adopted worldwide for myocardial perfusion imaging and for the diagnostic work-up of hyperparathyroidism. Furthermore there are reports on the use of 99mTc-MIBI imaging in post-surgical evaluation of thyroid ...

متن کامل

Tc-99m-Pertechnetate in evaluation of meckel's diverticulum [Persian]

Meckel's diverticulum is a common congenital disorder which may result in Gl bleeding. For definite diagnosis before surgery, radiographic procedures such as small intestine barium studies are not greatly successful; on the other hand Tc-99m-Pertechnetate imaging is a physiologic and noninvasive method with high sensitivity and specificity. In this report, three patients with rectorrhagia...

متن کامل

the evaluation of functioning thyroid nodules using sodium pertechnetate tc-99m scan in comparison with iodine-131

thyroid scintigraphy has been helpful in detecting and evaluation of thyroid nodules. sodium pertechnetate tc-99m is the most commonly used radionuclide for thyroid imaging because of its general availability, favorable dosimetric characteristics and low cost. but, there are reports of occasional disparity in isotope uptake in lesions compared with radioiodide. in order to determine percentage ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of radiation research

جلد ۱۴، شماره ۲، صفحات ۹۱-۹۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023